中图分类号 R965 文献标志码 A 文章编号 1001-0408(2025)11-1358-06

    DOI 10.6039/j.issn.1001-0408.2025.11.12

    ABSTRACT OBJECTIVE To study the efficacy of Tianjiang xueshuantong pills in the treatment of coronary heart disease.METHODS In accordance with the common pathogenesis of coronary heart disease， acute myocardial ischemia model，hyperlipidemia model，blood stasis model，and carotid artery thrombosis model were established using Wistar rats or SD rats as theexperimental subjects. The effects of Tianjiang xueshuantong pills administered at high，medium，and low doses(0.6，1.2 and 2.4g/kg ) on hemodynamic parameters and myocardial enzyme markers [lactate dehydrogenase (LDH)，creatine kinase-MB (CK-MB)]，oxidative stress factors [superoxide dismutase (SOD)，malondialdehyde (MDA)，glutathione (GSH)]，inflammatorycytokines [tumor necrosis factor- α (TNF- α_∝ )，interleukin-6(IL-6)，IL- ?1β ，monocyte chemotactic protein-1(MCP-1)，intercellular adhesion molecule-1 (ICAM-1)]， myocardial infarctionpercentage， serum lipid indexes [total cholesterol (TC)，triglycerides (TG)， low-density lipoprotein (LDL) ......