中图分类号 R973+.2 文献标志码 A 文章编号 1001-0408(2025)11-1384-05

    DOI 10.6039/j.issn.1001-0408.2025.11.17

    ABSTRACT OBJECTIVE To establish a clinical comprehensive evaluation framework for direct oral anticoagulants(DOACs) in the prevention of cancer-associated venous thromboembolism(CAVTE)，providing a methodological reference for the rational prevention and treatment of CAVTE as well as for the formulation and adjustment of macro-management strategies for anticoagulant drugs. METHODS Through literature retrieval，evaluation indicators were collected and organized to establish a preliminary indicator pool. The selection of evaluation indicators was carried out through two rounds of Delphi surveys using average score of indicator importance ?3.5 and a coefficient of variation(CV) lt;0.25 as the screening criteria. Analytic hierarchy process(AHP) was employed to finalize the indicator weights. RESULTS The authority levels (C_r) of the two rounds of expert consultations were 0.877 and 0.943，with CV of 0.24 and 0.18，respectively. The Kendall concordance coefficients were 0.331 and 0.535( Φ^-Plt;0.05 ). After expert validation ......