中图分类号R965；R285 文献标志码A 文章编号 1001-0408(2025)13-1617-05

    DOI 10.6039/j.issn.1001-0408.2025.13.11

    Effectsofastragaloside IV onarterial endothelial tissuedamage inratswith intracranial aneurysm

    CAI Qiang'，LIU Liuqing2，TANG Jiayul(1. Interventional Medical Center，Hunan Second People’s Hospital， Changsha ，China;2.Dept.of Neurology，Hunan Second People's Hospital，Changsha ，China)

    ABSTRACTOBJECTIVEToinvestigatetheefectofastragalosideV(AST)ontheinjuryofarterialendothelialtisse inrats with intracranial aneurysms (IA)，and to explore its mechanism of action based on the nuclear factor κB (NF- κB )/nucleotidebinding domain leucine-rich repeat and pyrin domain-containing protein 3(NLRP3)signaling pathway.METHODS Rats were dividedito Shamgroup(intragastricadministrationandintraperitoneal injectionofthesamevolumeofnormalsaline)，IAgroup (intragastricdministrationandintraperitonealinjectionofthesamevolumeofomalsaine)，ASTlow-dosegroup(AST-Lgroup， intragastric administration of 40mg/kg AST)，AST high-dose group(AST-H group，intragastric administration of 80mg/kg AST)， AST-H+HY-N2485 group [intragastric administration of 80mg/kg AST and intraperitoneal injection of 25mg/kg HY-N2485 (activator of NF- κB ......