中图分类号R965；R285 文献标志码A 文章编号 1001-0408(2025)13-1610-07

    DOI10.6039/j.issn.1001-0408.2025.13.10

    Mechanisms of paeoniflorin in treating hyperprolactinemia based on gut microbiota and metabolomics LIN Bingqi2，WEI Yuanyi2，YI Yun’，WANG Chunxia’(1.Dept. of Pharmacy，Nanfang Hospital，Southern Medical University，Guangzhou 510080，China;2.Dept.of Pharmacy，Women and Children’s Medical Center Affiliated to Guangzhou Medical University，Guangzhou 510623，China)

    ABSTRACTOBJECTIVETo investigate the mechanismsof paeoniflorin(PF) inanti-hyperprolactinemia(HPRL).METHODS Twenty-four female SD rats were divided into blank control group (intragastric administration of 5% gum arabic solution)， olanzapine group (model group，intragastric administration of 5mg/kg olanzapine suspension)，and PF group (intragastric administration of 5mg/kg olanzapine suspension，followed by gavaging with 50mg/kg PF solution 2 hours later)with 8rats in each group.Onceaday，continuouslymodel/administeruntil the plasma prolactin (PRL)levels intheolanzapine group were twiceas highasthoseintheblankcontrolgroup.PRLlevelswere measured.Techangesingut microbiotaofrats wereanalyzed ......