中图分类号R956；R735.2 文献标志码A 文章编号 1001-0408(2025)13-1629-06

    DOI 10.6039/j.issn.1001-0408.2025.13.13

    Cost-utility analysis of multiple sequential treatment regimens for HER-2 positive advanced gastric cancer LIUNana，GUAN Xin，HU Xia(School of InternationalPharmaceutical Business，China Pharmaceutical University，Nanjing ，China)

    ABSTRACTOBJECTIVEToevaluate thecost-effectivenessof diferentsequential treatmentregimens forhumanepidermal growth factorreceptor2(HER-2)-positiveadvancedgastriccancer fromtheperspectiveof the Chinese health system.METHODS Survival data wereobtained from the ToGA，WJOG4007 andRAINBOW-Asia trials，andadjustedusing network meta-analysis.A four-stateMarkovmodelwasconstructedtoevaluatethecost-effctivenessofsixtreatmentsequences，withalifetimesimulation horizonandacycleperiodof4weeks(28d)，andthemainoutput parametersofthe modelincludedtotalcosts，quality-adjusted life year(QALY)，andincrementalcost-ectivenessatio(CER)Sensitivityanalysis wasconductedtotesttheobustnsofte basicanalysisresults ......