复方磺胺甲噁唑及其代谢物血药峰浓度与危重症患者临床疗效及不良

复方磺胺甲噁唑及其代谢物血药峰浓度与危重症患者临床疗效及不良反应的相关性研究

http://www.100md.com 2025年8月18日中国药房 2025年第14期

    中图分类号R978.2 文献标志码A 文章编号 1001-0408(2025)14-1775-06

    DOI 10.6039/j.issn.1001-0408.2025.14.15

    ABSTRACT OBJECTIVE To analyze the correlation of the peak blood concentration (

)of compound sulfamethoxazole (TMP/SMZ)and its metabolite N. acetyl sulfamethoxazole (NSMZ)with clinical efficacy and adverse reactions in critically ill patients.METHODSThedataofcriticallyillpatientstreatedwithTMP/SMZinvariousICUofHainanGeneralHospitalfrom December 2023 to January 2025wereretrospectivelycolected.Thepatients were divided intosuccessgroupandfailuregroup basednthetreatmentoutcome.Simplelinearregressonand Speamancorelationanalysiswereused toanalyzethecorelationof TMP c_max ，SMZ c_max ，andNSMZ c_max with clinical efficacy and adverse reactions.The receiver operating characteristic curve (ROC) was used to determine the cutoff values of c_max forpredicting the occurrence of adverse reactions. REsULTS Among critically ill patients with an acute physiology and chronic health evaluation I (APACHE- II) ?15 points 24h of check-in at ICU ......

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