中图分类号R975 文献标志码A 文章编号 1001-0408(2025)14-1792-05

    DOI 10.6039/j.issn.1001-0408.2025.14.18

    ABSTRACTOBJECTIVEToevaluatetheeficacyandsafetyof high-doseilaprazolecombinedwithamoxiclinfornewly diagnosedelderlypatientswithHelicobacterpylori(Hp)infection，ndanalyzeindependentriskfactorsforfailureofHpinfection eradication treatmentMETHODSTotally2Ocasesof newlydiagnosedelderlypatientswithHpinfectioninXinxiangCentral Hospital fromAugust1，2021toDecember1，2024 wereselectedandrandomlydivided intocontrolgroupandstudygroup，with 100cases ineachgroup.Thecontrol groupwas treatedwithclasicquadrupletherapyregimen(Amoxicillncapsules+ Clarithromycintablets+Bismuthpotassumcitratetablets+Ilprazoleenteric-coatedtablets).Thestudygroupwastreatedwithhig doseIaprazoleenteric-coatedtablets+Amoxicilincapsules.Allpatientsereadministeredmedicationforweeks.Hperadication ratesintetwogroups werecomparedusing intention-to-treat(ITT)and per-protocol(PP)analyses.Theincidenceof adverse reactionsinbothgroupswasalsorecorded.Themultiple-factorLogisticregressonanalysiswasusedtoidentifyindependentrisk factors for failure of Hp infectioneradication treatment.RESULTSIn ITT andPPanalyses ......