人工智能与群体药动学模型在器官移植术后个体化用药中的应用与展望
ABSTRACTArtificial inteligence(AI)andpopulationpharmacokinetics(PPK)technologieshavedemonstratedsignificant potentialinthepersonalizedmedicationofimmunosuppressantsafterorgantransplantation，enablingprecisepredictionofdrug dosages.ThisarticleprovidesacomprehensivereviewoftheapplicationstatusofAIandPPKintheindividualizedadministration of immunosuppessntsafterorgan transplantation，focusesonmonitoringblooddrugconcentration，predictingeficacy/adverse reactions，andestablishingindividualizeddosingmodelsfororgantransplantrecipientsafterimmunosuppessntadministration，and analyzesandcomparestheappicationcharactersticsofdiferentmethodsindiferentorgantransplantpatientsaswellasthe integrationand futuredevelopmentofAIandPPKtechnologies.AIandPPKtechnologiescannotonlysignificantlyreducethe dependenceonhumanresources，butalsogreatlyimprovethelevelof individualizedtreatmentofimmunosuppresantsafterorgan transplantation，and reduce the discomfortand burdencausedby frequent bloodconcentrationmonitoring topatients.KEYWORDSartificial intelligence；population pharmacokinetics；organ transplantation； indiviualized medication ......
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