非编码RNA对骨关节炎的调控机制及中药干预研究进展

http://www.100md.com 2025年8月18日中国药房 2025年第14期

     中图分类号R965 文献标志码A 文章编号 1001-0408(2025)14-1819-06

    DOI 10.6039/j.issn.1001-0408.2025.14.23

    ABSTRACTOsteoarthritis(OA)isachronicdegenerativediseasecharacterizedprimarilybythedegenerationofarticular cartilage，withitspathogenesisinvolvingamultifactorialinterplayofinflammatoryresponses，chondrocyteapoptosis，and extracelular matrix(ECM)degradation.Non-codingRNA(ncRNA)participatesintheoccurrenceanddevelopment ofOAthrough theirdiverseregulatorypathways，providingnewpotentialtargetsforitstreatment.Thispapersystematicallyelucidatesthe mechanisms of ncRNA[micro ncRNA(miR)，circular ncRNA(circR)，and long ncRNA(IncR)] in regulating OA，as welas the current research statusoftraditional Chinesemedicine(TCM)intervening inOAbymodulatingncRNA.Itisfoundthat ncRNA participateinthepathologicalprocesssofOAbyconstructingamulti-layeredregulatorynetwork：miRinhibitsthetranslationof keytargetgenesandregulate downstreamsignaling pathways；circRcanactas‘molecularsponges’tocompetitivelyabsorbmRs forindirectregulationaswellasdirectlymodulateprotein functions；IncRpoess both‘molecularsponge’capabilitesandthe abilityto ntervene directlyin pathways.Andrograpolide ......

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