芍药甘草汤调控ASIC3(药学研究)

芍药甘草汤调控ASIC3/ERK信号通路改善慢传输型便秘大鼠肠道动力的机制研究

http://www.100md.com 2025年9月2日中国药房 2025年第15期

     中图分类号R965 文献标志码A 文章编号 1001-0408(2025)15-1852-07

    DOI 10.6039/j.issn.1001-0408.2025.15.06

    Study on the mechanism of Shaoyao gancao decoction in improving intestinal motility in rats with slow transit constipation by regulating the ASIC3/ERK signaling pathway

    ZHANG Ziqi12，ZHOU Hongyun1，ZHAO Qiong1，2，DENG Yuan3，ZHAO Mengjiel，ZHAO Chen4，CHEN Jingyi1， 2 (1.Dept.of Pediatrics，Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610075， China;2.Clinical Medical College，Chengdu University of Traditional Chinese Medicine，Chengdu 6137， China；3.Chongqing College of Traditional Chinese Medicine，Chongqing 402760，China；4.School of Pharmacy，Chengdu University of Traditional Chinese Medicine，Chengdu 611137，China)

    ABSTRACTOBJECTIVEToexplore the mechanismof Shaoyao gancao decoction inimproving intestinal motilityinrats with slowtransitconstipation(STC)byregulatingacid-sensitiveionchannel3(ASIC3)/extracelularsignal-regulatedkinase(ERK) signaling pathway.METHODS SDratswereused toconstruct anSTC model bygavage withcompound diphenoxylate.The successfully modeled rats were randomly divided into model group ......

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