中图分类号R965 文献标志码A 文章编号 1001-0408(2025)15-1882-05

    DOI 10.6039/j.issn.1001-0408.2025.15.11

    Improvement effect and mechanism of desloratadine citrate disodium in hypersensitivity pneumonitis model mice

    PENG Wenjuan’，ZHAO Yan2，YUE Shaoyun2，WU Yujiao2，MO Jiajia2，CHU Zhaoxing2(1.Dept.of Internal Medicine II，Anhui Chest Hospital，Hefei 230022，China;2.Hefei Industrial Pharmaceutical Institute Co.， Ltd.，Hefei 230601，China)

    ABSTRACTOBJECTIVETo investigate the improvement efectand mechanismof desloratadine citrate disodiuminmice with hypersensitivitypneumonitis(HP).METHODS Sixtymicewererandomlydividedintoblank control group(normalsaline)， model group(normal saline)，prednisone group(positive control， 20mg/kg )anddesloratadine citrate disodium low-，mediumand high-dose groups(0.5，1， 2mg/kg )，with 1O mice in each group.Except for the blank control group，mice in other groups wereintraperitoneallyinjectedwithovalbumin(OVA)andexposedtoOVAinhalationtoestablishtheHPmodel.Onday22postmodeling，miceineachgroupwereadministeredthecorrespondingdrugsornormalsaline ......