基于HPLC指纹图谱及一测多评法的心通颗粒质量评价

http://www.100md.com 2025年9月2日中国药房 2025年第15期

    中图分类号R917 文献标志码A 文章编号 1001-0408(2025)15-1866-05

    DOI 10.6039/j.issn.1001-0408.2025.15.08

    Qualityevaluation of Xintong granules basedon HPLC fingerprint and quantitative analysis of multi components by single-marker method

    YE Xide'，FENG Xiaolong1，SHAO Mingguo1，2，WAN Linchun3，HU Zhenyu’，CHEN Chunyu'，WU Yu¹ ，BU Junwen'，QIAN Yuhang'，MENG Fanqiang2(1. School of Pharmacy，Jiangxi University of Chinese Medicine， Nanchang 33004， China;2.Lunan Pharmaceutical Group Co.，Ltd.，Shandong Linyi 276006，China;3.Jiangxi InstituteforDrugControl，Nanchang330029，China)

    ABSTRACTOBJECTIVEToestablishthe HPLCfingerprintof Xintonggranulesand thequantitativeanalysisof multicomponents bysingle-marker method(QAMS)todetermine thecontentsof7components，soastoprovideascientific basis for theirqualitycontrol.METHODS HPLCmethodwasusedtoestablish thefingerprints for10batchesof Xintonggranules(No.S1- S10)，and similarityevaluation，cluster analysis(CA)and partial leastsquares-discriminant analysis (PLS-DA)wereperformed. At the same time ......

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