益肺宣肺降浊方通过抑制线粒体分裂抗血管性痴呆的作用研究

http://www.100md.com 2025年9月2日中国药房 2025年第15期

     中图分类号R965 文献标志码A 文章编号 1001-0408(2025)15-1859-07

    DOI 10.6039/j.issn.1001-0408.2025.15.07

    ∈键词血管性痴呆;益肺宣肺降浊方;线粒体分裂;HSP90/MLKL/Drpl信号通路

    Anti-vascular dementia effect of Yifei xuanfei jiangzhuo formula by inhibiting mitochondrial fission

    FU Yulan'，CHEN Wei2， ZHUO Guifeng'，ZHU Xiaomin1，HUANG Yingrui’，ZHANG Jinzhi1，YANG Fucai'， ZHANG Ying1，WU Lin³ (1.The First Clinical Collge，Guangxi University of Chinese Medicine，Nanning 530022，China;2.Dept.of Encephalopathy，Zone 1，the First Afliated Hospital of Guangxi University of Chinese Medicine，Nanning 530022，China;3.Graduate School，Guangxi University of Chinese Medicine， Nanning 530200，China)

    ABSTRACTOBJECTIVEToinvestigatetheinterventioneffectanditspotentialmechanismofYifei xuanfeijangzhuofomula byinhibiting mitochondrialfisioninavasculardementia(VaD)modelrats.METHODsVaDrat modelwas established by bilateralcommoncarotidarteryligation.Theexperimentalanimalswererandomlydividedintoshamoperationgroup(SHAM)， modelgroup(MOD)，Yifeixuanfeijiangzhuoformulalow-dose group(YFXF-L)，Yifeixuanfei jiangzhuoformulahigh-dosegroup (YFXF-H) ......

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