瑞芬太尼防治苏醒期躁动的作用机制及临床研究进展

http://www.100md.com 2025年9月2日中国药房 2025年第15期

     中图分类号R971+.2；R96 文献标志码A 文章编号1001-0408(2025)15-1947-06

    DOI 10.6039/j.issn.1001-0408.2025.15.23

    Mechanismand clinical research progressof remifentanil inthepreventionand treatment of emergence agitation

    WANG Na^1，2 ，DUAN Yongbo2.3，XIAO Zhongjie1，2，SONG Yujing1，2， YAN Wenjun2(1. First School of Clinical Medicine，Gansu University of Chinese Medicine，Lanzhou 730099，China;2.Dept.of Anesthesiology，Gansu Provincial Hospital，Lanzhou 7300l3，China；3.First School of Clinical Medicine，Lanzhou University， Lanzhou 730013，China)

    ABSTRACTEmergenceagitation(EA)isacommoncomplicationaftergeneralanesthesia，especiallinchildrenand adolescents.Remifentanil，as a short-acting μ -receptor agonist，has become an important drug for the prevention and treatment of EAduetoitsrapidrecoveryandlowriskofrespiratorydepresion.Thisarticlereviewsthemechanismofactionandclinical research progressofremifentanilinthepreventionandtreatmentofEA.Itsmechanismofactioninvolvestheinhibitioof pain signals mediated by traditional μ -receptor activation and potential new mechanism based on neural-endocrine-immune network ......

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