二甲双胍干预认知障碍相关疾病的作用机制研究进展

http://www.100md.com 2025年9月2日中国药房 2025年第15期

     中图分类号R965 文献标志码A 文章编号 1001-0408(2025)15-1942-05

    DOI 10.6039/j.issn.1001-0408.2025.15.22

    Research progressonthemechanismof metformininthe interventionof cognitiveimpairment-related diseases

    LIU Yuan1，2，XU Yumin1，2，3，LIU Shiyu1，2，YAN Huayu1，2，YANG Xin^1，2 ，XU Hongcai1，2，WU Yabol，2(1. Dept.of Encephalopathy，the First Afiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003， China；2.The First Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450046， China;3.Henan Province Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine，Zhengzhou 450046，China)

    ABSTRACTCognitiveimpairment(CI)isaclinicalsyndromecharacterizedbyprogresivedeclineinadvancedcognitive functionssuchasmemory，thinking，andjudgment.Itsetiologyandpathogenesis arecomplex，andthereiscurrentlyalackof specificdruginterventions.Metformin，asafirst-linehypoglycemicdrugfortype2diabetes，notonlylowersbloodglucoselevels but alsoimprovesCI.Thisarticlereviewsandsummarzes thepharmacological efectsand mechanismsof metformininimproving Alzheimer'sdisease ......

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