固体分散体技术对纳米雄黄稳定性及体外溶出的影响研究(5)
[17] 刘嵘,濮德敏,赵立波,等. 纳米雄黄混悬液诱导Siha细胞凋亡及对HPV16E6/E7表达的影响[J]. 中国中药杂志,2008, 33(1): 54.
Effect of stability and dissolution of realgar nano-particles
using solid dispersion technology
GUO Teng, SHI Feng, YANG Gang, FENG Nian-ping(College of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China)
[Abstract] Objective: To improve the stability and dissolution of realgar nano-particles by solid dispersion. Method: Using polyethylene glycol 6000 and poloxamer-188 as carriers, the solid dispersions were prepare by melting method. XRD, microscopic inspection were used to determine the status of realgar nano-particles in solid dispersions. The content and stability test of As203 were determined by DDC-Ag method. Hydride generation atomic absorption spectrometry was used to determine the content of Arsenic and investigated the in vitro dissolution behavior of solid dispersions. Result: The results of XRD and microscopic inspection showed that realgar nano-particles in solid dispersions were amorphous. The dissolution amount and rate of Arsenic from realgar nano-particles of all solid dispersions were increased significantly, the reunion of realgar nano-particles and content of As203 were reduced for the formation of solid dispersions. Conclusion: The solid dispersion of realgar nano-particles with poloxamer-188 as carriers could obviously improve stability, dissolution and solubility.
[Key words] realgar nano-particles; solid dispersion; stability; dissolution
doi:10.4268/cjcmm20131709
[责任编辑 曹阳阳], 百拇医药(郭腾 施峰 杨刚 冯年平)
Effect of stability and dissolution of realgar nano-particles
using solid dispersion technology
GUO Teng, SHI Feng, YANG Gang, FENG Nian-ping(College of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China)
[Abstract] Objective: To improve the stability and dissolution of realgar nano-particles by solid dispersion. Method: Using polyethylene glycol 6000 and poloxamer-188 as carriers, the solid dispersions were prepare by melting method. XRD, microscopic inspection were used to determine the status of realgar nano-particles in solid dispersions. The content and stability test of As203 were determined by DDC-Ag method. Hydride generation atomic absorption spectrometry was used to determine the content of Arsenic and investigated the in vitro dissolution behavior of solid dispersions. Result: The results of XRD and microscopic inspection showed that realgar nano-particles in solid dispersions were amorphous. The dissolution amount and rate of Arsenic from realgar nano-particles of all solid dispersions were increased significantly, the reunion of realgar nano-particles and content of As203 were reduced for the formation of solid dispersions. Conclusion: The solid dispersion of realgar nano-particles with poloxamer-188 as carriers could obviously improve stability, dissolution and solubility.
[Key words] realgar nano-particles; solid dispersion; stability; dissolution
doi:10.4268/cjcmm20131709
[责任编辑 曹阳阳], 百拇医药(郭腾 施峰 杨刚 冯年平)