固体分散技术和包合技术对白头翁总皂苷增溶作用研究(4)
[11] 袁超， 金征宇. 羟丙基-β-环糊精的结构[J]. 食品与生物技术学报，2007，26(4)： 34.
[12] Li J X， Zhang X S. Preparation and characterization of the inclusion complex of ofloxacin with β-CD and HP-β-CD[J]. Incl Phenom Macrocycl Chem， 2011， 69： 173.
Study on solubilization effect of solid dispersion technology and inclusion
technology on Pulsatillae total saponins
GUAN Yong-mei1， ZHANG Ni1， CHEN Zhen-hua2， LIU Hong-ning1， ZHU Wei-feng1， CHEN Li-hua1， YANG Ming1*
(1.Key Laboratory for Modern Preparation of Traditional Chinese Medicine， Ministry of Education， Nanchang 330004， China；
2. Jiangxi Science and Technology Normal University， Nanchang 330013， China)
[Abstract] Objective： To study the effect of solid dispersion technology and inclusion technology on dissolution performance of Pulsatillae total saponins， and preliminarily investigate its mechanism. Method： The solid dispersion of Pulsatillae total saponins-PEG 4000 was prepared by the melting method. The inclusion compound of Pulsatillae total saponins-hydroxypropyl-β-cyclodextrin(HP-β-CD) was prepared by the freeze-drying method. The properties of solid dispersion and inclusion compound were identified by using IR， DSC and NMR. And the dissolution of solid dispersion and inclusion compound were also determined by the small glass method. Result： IR， DSC and NMR results showed the formation of solid dispersion and inclusion compound. In terms of the dissolution， the inclusion compound ranked first， which was followed by solid dispersion and bulk pharmaceutical chemicals. Conclusion： The inclusion technology could significantly increase the dissolution of Pulsatillae total saponins， whereas the solid dispersion showed no notable solubilization effect.
[Key words] Pulsatillae total saponins； solid dispersion； inclusion compound； dissolution
doi：10.4268/cjcmm20132314, 百拇医药(管咏梅 张妮 陈振华 刘红宁 朱卫丰 陈丽华 杨明)
[12] Li J X， Zhang X S. Preparation and characterization of the inclusion complex of ofloxacin with β-CD and HP-β-CD[J]. Incl Phenom Macrocycl Chem， 2011， 69： 173.
Study on solubilization effect of solid dispersion technology and inclusion
technology on Pulsatillae total saponins
GUAN Yong-mei1， ZHANG Ni1， CHEN Zhen-hua2， LIU Hong-ning1， ZHU Wei-feng1， CHEN Li-hua1， YANG Ming1*
(1.Key Laboratory for Modern Preparation of Traditional Chinese Medicine， Ministry of Education， Nanchang 330004， China；
2. Jiangxi Science and Technology Normal University， Nanchang 330013， China)
[Abstract] Objective： To study the effect of solid dispersion technology and inclusion technology on dissolution performance of Pulsatillae total saponins， and preliminarily investigate its mechanism. Method： The solid dispersion of Pulsatillae total saponins-PEG 4000 was prepared by the melting method. The inclusion compound of Pulsatillae total saponins-hydroxypropyl-β-cyclodextrin(HP-β-CD) was prepared by the freeze-drying method. The properties of solid dispersion and inclusion compound were identified by using IR， DSC and NMR. And the dissolution of solid dispersion and inclusion compound were also determined by the small glass method. Result： IR， DSC and NMR results showed the formation of solid dispersion and inclusion compound. In terms of the dissolution， the inclusion compound ranked first， which was followed by solid dispersion and bulk pharmaceutical chemicals. Conclusion： The inclusion technology could significantly increase the dissolution of Pulsatillae total saponins， whereas the solid dispersion showed no notable solubilization effect.
[Key words] Pulsatillae total saponins； solid dispersion； inclusion compound； dissolution
doi：10.4268/cjcmm20132314, 百拇医药(管咏梅 张妮 陈振华 刘红宁 朱卫丰 陈丽华 杨明)