MicroRNA与高血压病(6)
MicroRNA and hypertension
DUAN Lian， XIONG Xing-jiang， WANG Jie(Department of Cardiology， Guang′anmen Hospital， China Academy of Chinese Medical Sciences， Beijing 100053， China)
[Abstract] MicroRNA(miRNA) is involved in virtually all biologic processes， including cellular proliferation， apoptosis， and differentiation. Thus， miRNA deregulation often results in impaired cellular function and disease development， so miRNAs have potential therapeutic relevance. The elucidation of these processes regulated by miRNAs and the identification of novel miRNA targets in the pathogenesis of hypertension is a highly valuable and exciting strategy that may eventually led to the development of novel treatment approaches for hypertension. Several mechanisms have been implicated in the pathogenesis of hypertension： overactivation of therenin-angiotensin-aldosterone system (RAAS)， dysfunction of the vascular endothelium， damnification of vascular smooth muscle. To maintain and restore target organ expression of miRNA stable may be a new strategy for treatment of hypertension. The article reviews pathogenesis of miRNA and hypertension， researches of miRNAs as biomarker and therapeutic target， discusses advances in miRNA-based approaches that may be important in treating hypertension.
[Key words] miRNA； hypertension； pathogenesis； treatment； review
doi：10.4268/cjcmm20140308
[责任编辑 陈玲], http://www.100md.com(段练 熊兴江 王阶)
DUAN Lian， XIONG Xing-jiang， WANG Jie(Department of Cardiology， Guang′anmen Hospital， China Academy of Chinese Medical Sciences， Beijing 100053， China)
[Abstract] MicroRNA(miRNA) is involved in virtually all biologic processes， including cellular proliferation， apoptosis， and differentiation. Thus， miRNA deregulation often results in impaired cellular function and disease development， so miRNAs have potential therapeutic relevance. The elucidation of these processes regulated by miRNAs and the identification of novel miRNA targets in the pathogenesis of hypertension is a highly valuable and exciting strategy that may eventually led to the development of novel treatment approaches for hypertension. Several mechanisms have been implicated in the pathogenesis of hypertension： overactivation of therenin-angiotensin-aldosterone system (RAAS)， dysfunction of the vascular endothelium， damnification of vascular smooth muscle. To maintain and restore target organ expression of miRNA stable may be a new strategy for treatment of hypertension. The article reviews pathogenesis of miRNA and hypertension， researches of miRNAs as biomarker and therapeutic target， discusses advances in miRNA-based approaches that may be important in treating hypertension.
[Key words] miRNA； hypertension； pathogenesis； treatment； review
doi：10.4268/cjcmm20140308
[责任编辑 陈玲], http://www.100md.com(段练 熊兴江 王阶)