基于关联规则方法对不同地区乌头组反药的临床调查研究和配伍特点分析(1)
[摘要]目的：通过对华东、华中不同地区3家医院“十八反”中乌头组反药应用情况进行临床调研和对比分析，探讨“十八反”乌头组反药同方配伍在临床应用的现状及特点。方法：从不同地区的临床应用处方中收集含乌头组“十八反”药对的处方，采用关联规则的方法分析药物的配伍特点。结果：“十八反”同方配伍分析显示，在两地区的临床处方中出现的频率较高的药对是附子-半夏的配伍，支持度为44.45%，占有较大的比重，达到所有调研处方的一半;两地区使用频率最高的药物是半夏，支持度达到76.24%;取支持度前10的药物比较，核心药物除附子、半夏外，华中地区前10的药物多是温中补气类药物，如干姜、白术、党参等，而华东地区前10的药物多是活血养血类药物，如当归、川芎、丹参等;取支持度前10的药对比较，除附子-半夏外，华中地区临床应用的核心药对主要为化痰温中类药物配伍，如半夏-甘草、半夏-干姜等;而华东地区则主要是以活血补气类药物配伍，如白术-半夏、当归-半夏等;在两地区处方中出现的核心药组频率最高的为附子-甘草-半夏三药的配伍，支持度高达59.73%，在所有药组的应用中，所占的比例最大。结论：临床存在“十八反”乌头组反药同方配伍应用情况，其中以附子与半夏的配伍应用为多，但是“十八反”同方配伍药物在两地区临床上的应用有一定的差异。
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[关键词]十八反;乌头组;同方配伍;数据挖掘
Clinicalstudyonaconiteprescriptionswithincompatibleherbsindifferentareas
basedonassociationrulesandanalysisoncompatibilityfeatures
ZUOTing1，2，FANXin-sheng/1*，TIANShuo/1，JIANGChen-xue/1，CHENFei/1
(1.NanjingUniversityofChineseMedicine，Nanjing210023，China;
2.He′nanCollegeofTraditionalChineseMedicine，Zhengzhou450046，China)
, http://www.100md.com
[Abstract]Objective：ToexplorethecurrentapplicationandfeaturesofAconiteprescriptionswithincompatibleherbsingradeAclassthreehospitalsineastChinaandcentralChinathroughaclinicalstudyandcomparativeanalysis.Method：ClinicalprescriptionscontainingAconitewithincompatibleherbswerecollected.Associationruleswereutilizedtoanalyzethecompatiblefeaturesoftheseherbs.Result：Thisanalysisfoundthatthefrequentlyusedincompatibleherba;pairsareAconitiLateralisRadixPraeparata-PinelliaeRhizoma，withthesupportrateof44.45%，occupyingnearlyhalfofthesurveyedprescriptions;PinelliaeRhizomaisthemostfrequentlyusedherbinthetwoareas，withsupportrateupto76.24%.Amongthetop10herbalpairsinthesupportrate，exceptforAconitiLateralisRadixPraeparataandPinelliaeRhizoma，thetop10herbsinCentralChinaweremostlyforwarmingthemiddlejiaoandtonifyingqi，suchasZingiberisRhizoma，AtractylodisMacrocephalaeRhizomaandCodonopsisRadix;WhereasthoseineastChinaweremostlyforactivatingandnourishingblood，suchasAngelicaeSinensisRadix，ChuanxiongRhizoma，andSalviaeMiltiorrhizaeRadixetRhizoma.Amongthetop10herbalpairsinthesupportrate，exceptforAconitiLateralisRadixPraeparata-PinelliaeRhizoma，thecoreherbalpairsappliedincentralChinaweremainlyforresolvingphlegmandwarmingthemiddlejiao，suchasPinelliaeRhizoma-GlycyrrhizaeRadixetRhizoma，PinelliaeRhizoma-ZingiberisRhizoma;WhereasthoseineastChinawereprincipallyforactivatingbloodandtonifyingqi，likeAtractylodisMacrocephalaeRhizomaandPinelliaeRhizoma，AngelicaeSinensisRadixandPinelliaeRhizoma.Amongthecoreherbalgroupsinthetwoareas，themostfrequentlyusedherbalgroupsinthetwoareasareAconitiLateralisRadixPraeparata，GlycyrrhizaeRadixetRhizomaandPinelliaeRhizomawiththesupportrateof59.73%，accountingforthehighestproportionamongallofherbalgroups.Conclusion：TherearethecombinedclinicalapplicationofAconitewithincompatibleherbs，mostlywithAconitiLateralisRadixPraeparata-PinelliaeRhizoma，butwithdifferencesinthecombinedapplicationineastChinaandcentralChina., 百拇医药(左艇 范欣生 田硕 蒋辰雪 陈菲)
, http://www.100md.com
[关键词]十八反;乌头组;同方配伍;数据挖掘
Clinicalstudyonaconiteprescriptionswithincompatibleherbsindifferentareas
basedonassociationrulesandanalysisoncompatibilityfeatures
ZUOTing1，2，FANXin-sheng/1*，TIANShuo/1，JIANGChen-xue/1，CHENFei/1
(1.NanjingUniversityofChineseMedicine，Nanjing210023，China;
2.He′nanCollegeofTraditionalChineseMedicine，Zhengzhou450046，China)
, http://www.100md.com
[Abstract]Objective：ToexplorethecurrentapplicationandfeaturesofAconiteprescriptionswithincompatibleherbsingradeAclassthreehospitalsineastChinaandcentralChinathroughaclinicalstudyandcomparativeanalysis.Method：ClinicalprescriptionscontainingAconitewithincompatibleherbswerecollected.Associationruleswereutilizedtoanalyzethecompatiblefeaturesoftheseherbs.Result：Thisanalysisfoundthatthefrequentlyusedincompatibleherba;pairsareAconitiLateralisRadixPraeparata-PinelliaeRhizoma，withthesupportrateof44.45%，occupyingnearlyhalfofthesurveyedprescriptions;PinelliaeRhizomaisthemostfrequentlyusedherbinthetwoareas，withsupportrateupto76.24%.Amongthetop10herbalpairsinthesupportrate，exceptforAconitiLateralisRadixPraeparataandPinelliaeRhizoma，thetop10herbsinCentralChinaweremostlyforwarmingthemiddlejiaoandtonifyingqi，suchasZingiberisRhizoma，AtractylodisMacrocephalaeRhizomaandCodonopsisRadix;WhereasthoseineastChinaweremostlyforactivatingandnourishingblood，suchasAngelicaeSinensisRadix，ChuanxiongRhizoma，andSalviaeMiltiorrhizaeRadixetRhizoma.Amongthetop10herbalpairsinthesupportrate，exceptforAconitiLateralisRadixPraeparata-PinelliaeRhizoma，thecoreherbalpairsappliedincentralChinaweremainlyforresolvingphlegmandwarmingthemiddlejiao，suchasPinelliaeRhizoma-GlycyrrhizaeRadixetRhizoma，PinelliaeRhizoma-ZingiberisRhizoma;WhereasthoseineastChinawereprincipallyforactivatingbloodandtonifyingqi，likeAtractylodisMacrocephalaeRhizomaandPinelliaeRhizoma，AngelicaeSinensisRadixandPinelliaeRhizoma.Amongthecoreherbalgroupsinthetwoareas，themostfrequentlyusedherbalgroupsinthetwoareasareAconitiLateralisRadixPraeparata，GlycyrrhizaeRadixetRhizomaandPinelliaeRhizomawiththesupportrateof59.73%，accountingforthehighestproportionamongallofherbalgroups.Conclusion：TherearethecombinedclinicalapplicationofAconitewithincompatibleherbs，mostlywithAconitiLateralisRadixPraeparata-PinelliaeRhizoma，butwithdifferencesinthecombinedapplicationineastChinaandcentralChina., 百拇医药(左艇 范欣生 田硕 蒋辰雪 陈菲)