木犀草素对对乙酰氨基酚诱导的L02肝细胞损伤的保护作用(4)
综上所述,木犀草素通过抑制氧化应激和细胞凋亡实现其对APAP诱导的L02细胞损伤的保护作用。其机制可能与抑制脂质过氧化,增强GSH和SOD活性,同时下调Bax和caspase3 mRNA及上调Bcl2 mRNA的表达有关,但详细机制还有待进一步探讨。
[参考文献]
[1] Jaeschke H, Williams C D, Ramachandran A, et al. Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity[J]. Liver Int, 2012, 32: 8.
[2] Chun L J, Tong M J, Busuttil R W, et al. Acetaminophen hepatotoxicity and acute liver failure[J]. J Clin Gastroenterol ......
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[参考文献]
[1] Jaeschke H, Williams C D, Ramachandran A, et al. Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity[J]. Liver Int, 2012, 32: 8.
[2] Chun L J, Tong M J, Busuttil R W, et al. Acetaminophen hepatotoxicity and acute liver failure[J]. J Clin Gastroenterol ......
您现在查看是摘要页,全文长 3437 字符。