孕中期羊水母体血清甲胎蛋白水平与不良妊娠结局分析

孕中期羊水母体血清甲胎蛋白水平与不良妊娠结局分析(1)

http://www.100md.com 2015年8月1日右江医学 2015年第4期

     【摘要】目的了解孕中期羊水母体血清甲胎蛋白(AFP)水平及其与不良妊娠的关系。方法对25 038例孕中期孕妇羊水采用酶联免疫吸附法进行AFP检测，随访妊娠结局，建立羊水AFP参考值及2.5中位数倍数(MoM)。结果孕16～23 W羊水参考值上限为15 665.6～28 766.9 ng/ml，2.5 MoM为18 712.3～38 694.3 ng/ml，且其值随孕周增加而降低，开放神经管缺陷、颈部淋巴管瘤、死胎和腹部畸形妊娠羊水AFP异常比例较高，其他不良妊娠结局则较低，但其AFP值明显增加。结论羊水AFP异常升高与神经管缺陷、颈部淋巴管瘤、死胎和腹部畸形等不良妊娠相关，但仍有一定漏诊和误诊，应结合动态超声监测以确诊和排除相关畸形。

    【关键词】羊水；甲胎蛋白；不良妊娠结局

    中图分类号：R714.53文献标识码：ADOI：10.3969/j.issn.10031383.2015.04.006

    【Abstract】ObjectiveTo investigate relationship between level of amniotic fluid alphafetoprotein(AFP) in second trimester and adverse pregnancy outcomes.MethodsEnzymelinked immunosorbent assay was used to detect amniotic fluid AFP of 25 038 pregnant women in second trimester.And pregnancy outcomes were followed up.Reference values of amniotic fluid AFP and 2.5 multiple of median(MoM) were established.Results Upper limit of normal amniotic fluid was 15 665.6～28 766.9 ng/ml and 2.5 MoM was 18 712.3～38 694.3 ng/ml during 16～23 weeks of pregnancy ......

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