马晓红 欧远贵 覃艺 封华海

    【摘要】 目的 探讨小剂量肝素治疗儿童重症水痘并脓毒症的临床疗效和安全性。方法 选取2019年1月至2022年12月收治的51例重症水痘并脓毒症患儿的临床资料，根据是否使用小剂量肝素治疗分为研究组28例与对照组23例，入院后两组患儿均予针对病因、脏器支持等综合治疗，研究组同时加用小剂量肝素辅助治疗，比较两组小儿危重症评分(PCIS)、凝血功能指标、PLT水平、弥散性血管内凝血(DIC)和多脏器功能障碍(MODS)的发生率以及住院时间。结果 治疗后研究组与对照组比较，D-二聚体水平显著下降，APTT、PT显著缩短，PLT水平显著升高，差异均有统计学意义(P0.05); the incidence of DIC and MODS in the study group was 17.9% and 14.3%， respectively， significantly lower than that in the control group(43.4% and 39.1%)， and difference was statistically significant between the two groups (P<0.05); the length of stay of the study group was shorter than that of the control group， and the PCIS score was higher than that of the control group， and the difference between the two groups was statistically significant (P<0.05 or 0.001).Conclusion For children with severe chickenpox and sepsis accompanied by coagulation dysfunction， low-dose heparin can improve coagulation function， protect organ function， reduce the incidence of DIC and MODS， shorten the length of hospital stay ......