中图分类号：R774.1 文献标志码：A DOI：10.3969/j.issn.1003-1383.2025.07.002

    【Abstract】ObjectiveTo studythekeytargetsand mechanismsof puerarininthetreatment ofretinal veinocclusion (RVO)basedonnetwork pharmacologyand moleculardocking technology.MethodsThechemical structureinformationof puerarin was adopted，and thenthetargets of puerarin weresearched through SwissTargetPredictiondatabase and SuperPred database，andRVO-related targets wereobtained through GeneCards database and OMIMdatabase.The intersectionbetween the targetsofpuerarinandtheRVO-related targets were taken，andthenthepotentialtargetsof puerarinfor treating RVO wereobtained.Protein-protein interaction(PPI)analysis wasconductedontheSTRING platform，andtheresultswere visualizedandcalculatedbyCytoscape3.1O.3software，soastoobtainthepotentialkeytargetsof puerarinfortreatingRVO. Geneontology(GO)functional enrichment and Kyoto encyclopedia of genesand genomes(KEGG)pathway analysis were performed with Metascape Version3.5 to explore the potential mechanismsbywhich puerarinactedagainstretinal veinocclusion(RVO).Inaddition，moleculardocking technology wereemployedto validatethebinding afinities between puerarin anditskeytargets.ResultsAfterscrening ......