中图分类号：R743.33 文献标志码：A DOI：10.3969/j.issn.1003-1383.2025.07.004

    【Abstract】ObjectiveTo explore thecausal relationship between blood metabolitesandcerebral infarction(CI)by two-sample two-way Mendelian randomization(MR)analysis.MethodsThe published genome-wide asociation studies (GWAS)dataof cerebral infarction were obtained from public database.Witha GWAScontaining 140O circulating metabolitesas an exposure indicator，SNPswhich stronglyrelated to exposure factors wereselected as instrumental variables (IV). Thecausalrelationshipbetween140ObloodmetabolitesandcerebralinfarctionwasanalyzedbyR4.3.2software.Fivemethods—MR-Egger regresson，inverse-variance weighted (IVW)，weighted median，simple mode，and weighted mode—were employedtoasessheterogeneity，pleiotropy，andsensitivity，therebyverifying therobustnessoftheresults.Finall，a reverse MRanalysis was performedon theobtained results.ResultsIVW method was used to assess causal relationship betweenblood metabolitesand CI，and the results showed that urea (OR=0.997，95%CI： 0.996-0.999)wasa protectivefactor，andtheriskofCIdecreasedwiththeincreaseofmetaboliteurea.ThereverseMRresultsshowedthattherewas nocausalrelationshipbetweenthediseaseandthe metabolites.ConclusionUreahasaninhibitoryefectoncerebral infarction ......