【关键词】线粒体自噬;糖尿病心肌病；糖尿病;线粒体质量控制;降糖药物 中图分类号：R587.2 文献标志码：A DOI：10.3969/j.issn.1003-1383.2025.07.001

    【Abstract】 Diabeticcardiomyopathy(DCM)isanon-ischemic，non-hypertensivemyocardial disorder induced bymetabolic disturbancesinpatientswitabeteselltus(D)，nditsignficantlyaectsprogosisndmortalityAstecentraloranellfor celularnergymetabolism，mitochondrialdysfunctionrepresentsakeypathologicalmechanisminDCM.Mitophagy，asaritical componentofmitochondrialqualitycontrol，laysadualregulatoryroleinDCMprogresionbyselectivelyremovingdamagedordysfunctionalmitochondria.Tiseviewsystematicallsummarizesthemolecularmechanismsofmitophagy，includingubiquitin-dpedent pathways (PINK1/Parkin pathway)，receptor-mediated pathways(FUNDC1，BNIP3/NIX，PHB2，etc.)，and pathways mediated by TFEB/calcineurinItalsoexploresthiroesinDCM(suchastime-dependentchanges inutopagyinHFDmodels，potentialdetrimental ffectsofenhancedautopagyinTD)andsynthesizesresearchprogressonhowantidiabeticdrugs(empagliflozin ......