【关键词】miR-1184；I型胶原α1链(COL1A1);PI3K/Akt;胃癌;细胞功能 中图分类号：R735.2 文献标志码：A DOI：10.3969/j.issn.1003-1383.2025.09.002

    Effects of miR-1184 targeting COL1A1 on the proliferation， invasion， and apoptosis of gastric cancer cells via regulation of the PI3K/Akt signaling pathway

    YANG Lu ?^a ，ZHENG Xin μ^u ，WANG Xin ?^b ， ZHANG Liwei°， ZHANG Weia (a. Department of Gastroenterology，b. Department of General Surgery，the Second Afliated Hospital of QiqiharMedical University，Qiqihar161oOo，Heilongjiang，China)

    【Abstract】ObjectiveToinvestigate theexpresionand biological functionsof miR-184ingastriccancer，andfurther explore whether it affects the PI3K-Akt signaling pathwaybyregulating thecollagen type I alpha 1(COL1A1)，andits efectsontheproliferation，invasionandapoptosisof gastriccancercells.MethodsSamplesofsomecancer tisues(30cases)andadjacent tisues(3Ocases)of patients with primary gastriccancer whounderwentsurgicalresectionat the Second Affiliated HospitalofQiqihar Medical UniversityfromOctober 2022 toAugust2O23werecolected.Theexpresionlevelsof miR-1184 ......