许柳

    【摘 要】目的 分析血液透析结合血液灌流在尿毒症皮肤瘙痒患者中的应用效果。方法 选取我院2020年4月-2022年6月收治的78例尿毒症且伴有皮肤瘙痒患者作为研究对象，采用随机数字表法分为对照组与观察组，每组39例。对照组进行血液透析治疗，观察组在对照组基础上结合血液灌流治疗，比较两组血钙、磷、甲状旁腺激素(PTH)水平、肾功能指标[血尿素氮(BUN)、血清肌酐(Scr)、血β2-微球蛋白(β2-MG)]及皮肤瘙痒情况。结果 观察组治疗后1、3个月血钙水平高于对照组，血磷及PTH水平均低于对照组(P<0.05)；观察组治疗后1、3个月BUN、Scr、β2-MG水平均低于对照组(P<0.05)；观察组治疗后皮肤瘙痒评分低于对照组(P<0.05)。结论 血液透析结合血液灌流在尿毒症皮肤瘙痒患者中的应用效果确切，与单纯血液透析治疗相比，调节钙磷代谢、清除体内中分子物质的效果更好，还能有效改善患者皮肤瘙痒症状，值得临床应用。

    【关键词】血液透析；血液灌流；尿毒症；皮肤瘙痒；甲状旁腺激素

    中图分类号：R758.3+1 文献标识码：A 文章编号：1004-4949(2023)02-0026-04

    Application Effect of Hemodialysis Combined with Hemoperfusion in the Treatment of Patients with Uremic Pruritus

    XU Liu

    (Langfang Comprehensive Outpatient Department of Xinyi Health Management Co.， Ltd.， Langfang 065000， Hebei， China)

    【Abstract】Objective To analyze the application effect of hemodialysis combined with hemoperfusion in the treatment of patients with uremic pruritus. Methods A total of 78 patients with uremia pruritus admitted to our hospital from April 2020 to June 2022 were selected as the research objects. They were divided into control group and observation group by random number table method ......