杨钞茗

    【摘 要】瘢痕因机体受到外伤，诸如烧伤、创伤、擦挫伤等后愈合所形成，表现为独特的外形及病理学改变。伤口愈合过程伴随着瘢痕的产生，瘢痕增生会对外观及功能产生严重不良影响，特别是烧伤、烫伤及严重外伤后所形成的瘢痕，会给患者带来巨大的肉体和精神痛苦。透明质酸是一种生物大分子，在介导组织修復过程中具有多方面的作用，在伤口愈合的炎症激活、肉芽形成、再上皮化过程3个阶段都有参与。近年来，透明质酸作为一种防治瘢痕的新方法已被广泛应用于临床，本文将透明质酸对瘢痕的防治机制及临床应用进行综述，以期为相关临床工作提供一定参考。

    【关键词】透明质酸；伤口愈合；增生性瘢痕；瘢痕疙瘩

    中图分类号：R619+.6 文献标识码：A 文章编号：1004-4949(2023)09-0191-04

    Research Progress of Hyaluronic Acid in Scar Prevention and Treatment

    YANG Chao-ming1， 2

    (1.Graduate School of North Sichuan Medical College， Nanchong 637000， Sichuan， China； 2.Department of Burn Plastic and Aesthetic Surgery， Nanchong Central Hospital， Nanchong 637000， Sichuan， China)

    【Abstract】Scar is formed by the healing of the body after trauma， such as burns， trauma， abrasions， etc.， showing unique appearance and pathological changes. The process of wound healing is accompanied by the generation of scars. Scar hyperplasia can have serious adverse effects on appearance and function， especially the scars formed after burns， scalds and severe trauma， which will bring huge physical and mental pain to patients. Hyaluronic acid is a kind of biological macromolecules ......