【摘 要】目的 探究针对角化过度型手足癣患者采用伊曲康唑口服联合盐酸布替萘芬乳膏外用治疗的临床效果。方法 选取我院皮肤科2022年1月-2023年1月收治的80例角化过度型手足癣患者为研究对象，根据治疗方法不同分为对照组和研究组，每组40例。对照组予以盐酸布替萘芬乳膏外用治疗，研究组予以伊曲康唑胶囊口服联合盐酸布替萘芬乳膏外用治疗，比较两组临床疗效、不良反应发生情况及复发情况。结果 研究组治疗总有效率为95.00%，高于对照组的60.00%，差异有统计学意义(P<0.05)；两组不良反应发生率比较，差异无统计学意义(P>0.05)；研究组治疗后1、3、6个月复发率均低于对照组，差异有统计学意义(P<0.05)。结论 伊曲康唑口服联合盐酸布替萘芬乳膏外用治疗角化过度型手足癣的临床效果良好，可有效改善患者的临床症状，降低复发率，同时不会增加不良反应发生风险。

    【关键词】角化过度型手足癣；伊曲康唑；盐酸布替萘芬乳膏

    中图分类号：R756.3 文献标识码：A 文章编号：1004-4949(2023)21-0091-04

    Clinical Effect of Oral Itraconazole Combined with Butenafine Hydrochloride Cream in the Treatment of Hyperkeratotic Tinea of Feet and Hands

    QIAN Jia-li， WANG Fei-fei， LIU Jiu-li

    (Department of Dermatology， Shunyi Hospital， Beijing Hospital of Traditional Chinese Medicine， Beijing 101300， China)

    【Abstract】Objective To explore the clinical effect of itraconazole January oral combined with butenafine hydrochloride cream in the treatment of hyperkeratotic tinea of feet and hands. Methods A total of 80 patients with hyperkeratotic tinea of feet and hands admitted to the Department of Dermatology of our hospital from January 2022 to January 2023 were selected as the research objects. According to different treatment methods ......