[摘 要]目的 探究CO2点阵激光联合他克莫司治疗白癜风的效果。方法 选取2020年1月-2021年12月我院收治的白癜风患者70例作为研究对象，根据随机数字表法分为对照组和观察组，各35例。对照组采取单纯复方甘草酸苷片联合他克莫司治疗，观察组采取CO2点阵激光联合他克莫司治疗，比较两组氧化应激指标[超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH-Px)、丙二醛(MDA)]、Treg细胞、相关细胞因子叉头框蛋白P3(Foxp3)、临床疗效及并发症发生情况。结果 观察组治疗后SOD、GSH-Px、MDA、Treg细胞及Foxp3均优于对照组(P<0.05)；观察组治疗总有效率为97.14%，高于对照组的82.86%(P<0.05)；观察组并发症发生率为17.14%，低于对照组的42.86%(P<0.05)。结论 CO2点阵激光联合他克莫司治疗白癜风的效果肯定，可有效减轻应激损伤，改善免疫功能，且安全性较高。

    [关键词] CO2点阵激光；他克莫司；白癜风；氧化应激

    [中图分类号] R758.4 [文献标识码] A [文章编号] 1004-4949(2024)04-0001-04

    Clinical Effect of CO2 Fractional Laser Combined with Tacrolimus in the Treatment of Vitiligo

    WANG Xian-fen

    (Dermatology Department of Yinshanhu Hospital， Wuzhong District， Suzhou 215000， Jiangsu， China)

    [Abstract]Objective To explore the effect of CO2 fractional laser combined with tacrolimus in the treatment of vitiligo. Methods A total of 70 patients with vitiligo admitted to our hospital from January 2020 to December 2021 were selected as the research objects. According to the random number table method， they were divided into control group and observation group ......