[摘 要]目的 分析激光与吡美莫司乳膏及他克莫司软膏联合治疗白癜风的临床效果。方法 选取北京京城皮肤医院皮肤科2022年6月-12月收治的82例白癜风患者为研究对象，采用随机数字表法分为常规组和联合组，各41例。常规组予以激光治疗，联合组在激光治疗基础上应用吡美莫司乳膏及他克莫司软膏联合治疗，比较两组临床疗效、免疫功能、症状改善情况及不良反应发生情况。结果 联合组治疗总有效率为97.56%，高于常规组的82.93%，差异有统计学意义(P<0.05)；联合组治疗后IgA、IgM及IgG水平高于常规组，差异有统计学意义(P<0.05)；联合组治疗后白斑数量少于常规组，白斑面积小于常规组，差异有统计学意义(P<0.05)；联合组不良反应发生率为7.32%，低于常规组的29.27%，差异有统计学意义(P<0.05)。结论 激光与吡美莫司乳膏及他克莫司软膏联合治疗白癜风可提高治疗效果，提升机体免疫功能，减少白斑个数和白斑面积，降低不良反应发生几率，值得临床应用。

    [关键词] 激光治疗；吡美莫司乳膏；他克莫司软膏；白癜风

    [中图分类号] R758.4+1 [文献标识码] A [文章编号] 1004-4949(2024)04-0005-04

    Clinical Effect of Laser Combined with Pimecrolimus Cream and Tacrolimus Ointment in the Treatment of Vitiligo

    YIN Cui-hong1， YIN Zhi-yu2

    (1.Department of Dermatology， Beijing Jingcheng Skin Hospital， Beijing 100101， China； 2.Beijing Anzhen Hospital， Capital Medical University， Beijing 100029， China)

    [Abstract]Objective To analyze the clinical effect of laser combined with pimecrolimus cream and tacrolimus ointment in the treatment of vitiligo. Methods A total of 82 patients with vitiligo admitted to the Department of Dermatology， Beijing Jingcheng Skin Hospital from June to December 2022 were selected as the research objects. They were divided into conventional group and combined group by random number table method ......