苏婧 孙君儒

    [摘 要]目的 探讨CO2点阵激光联合他克莫司治疗白癜风的临床效果。方法 选择2020年1月-2023年10月我院收治的白癜风患者94例为研究对象，采用简单抽样法分为对照组和观察组，各47例。对照组采用他克莫司软膏治疗，观察组在对照组基础上联合CO2点阵激光治疗，比较两组白癜风皮损面积与严重指数评分(VASI)、白癜风活动性评分(VIDA)、皮损分布评分、炎症因子水平(TNF-α、ICAM-1、IL-17、TGF-β1)及不良反应发生率。结果 观察组干预4周后VASI、VIDA及皮损分布评分低于对照组(P0.05)。结论 CO2点阵激光联合他克莫司治疗白癜风的效果较好，能减轻临床症状及皮损分布情况，降低体内炎症反应，且治疗安全性较高。

    [关键词] CO2点阵激光；他克莫司；白癜风；炎症因子；白癜风活动性评分；白癜风皮损面积与严重指数评分

    [中图分类号] R758.5+4 [文献标识码] A [文章编号] 1004-4949(2024)05-0073-04

    Effect of CO2 Fractional Laser Combined with Tacrolimus in the Treatment of Vitiligo

    SU Jing， SUN Jun-ru

    (Department of Dermatology， Qinghai Red Cross Hospital， Xining 810000， Qinghai， China)

    [Abstract]Objective To investigate the clinical effect of CO2 fractional laser combined with tacrolimus in the treatment of vitiligo. Methods A total of 94 patients with vitiligo admitted to our hospital from January 2020 to October 2023 were selected as the research objects. They were divided into control group and observation group by simple sampling method ......