苏婧 孙君儒

    [摘 要]目的 探討点阵CO2激光联合吡美莫司乳膏外用治疗白癜风的临床效果。方法 选择2020年1月-2023年6月青海红十字医院收治的80例白癜风患者为研究对象，随机分为观察组与对照组，各40例。对照组采用吡美莫司乳膏外用治疗，观察组在对照组基础上联合点阵CO2激光治疗，比较两组T淋巴细胞水平、白斑面积、生活质量(DLQI)评分、氧化应激指标及安全性。结果 两组治疗后CD3+、CD4+、CD8+及CD4+/CD8+均优于治疗前，且观察组优于对照组(P0.05)。结论 点阵CO2激光联合吡美莫司乳膏外用治疗白癜风能调节患者T淋巴细胞水平，缩小白斑面积，提高患者生活质量，有助于减轻氧化应激水平，且治疗安全性较高，值得临床应用。

    [关键词] 点阵CO2激光；吡美莫司乳膏；白癜风；T淋巴细胞水平；白斑面积；氧化应激

    [中图分类号] R758.4+1 [文献标识码] A [文章编号] 1004-4949(2024)06-0079-04

    Clinical Effect of CO2 Fractional Laser Combined with Pimecrolimus Cream in the Treatment of Vitiligo

    SU Jing， SUN Jun-ru

    (Department of Dermatology， Qinghai Red Cross Hospital， Xining 810000， Qinghai， China)

    [Abstract]Objective To investigate the clinical effect of CO2 fractional laser combined with pimecrolimus cream in the treatment of vitiligo. Methods A total of 80 patients with vitiligo admitted to Qinghai Red Cross Hospital from January 2020 to June 2023 were randomly divided into observation group and control group ......