[摘 要]目的 探究采取570 nm强脉冲光联合果酸治疗黄褐斑的临床效果。方法 选取成都三六三医院皮肤科2022年5月-2023年2月收治的57例黄褐斑患者为研究对象，随机分为常态组(n=28)及考察组(n=29)。常态组予以570 nm强脉冲光治疗，考察组在常态组基础上予以果酸治疗，比较两组临床疗效、皮肤情况、氧化应激指标水平及不良反应发生情况。结果 考察组治疗总有效率为96.55%，高于常态组的71.43%，差异有统计学意义(P<0.05)；考察组治疗后皮肤破损评分、角质层含水量、经表皮水分流失量优于常态组，差异有统计学意义(P<0.05)；考察组治疗后血清丙二醛、超氧化物歧化酶、谷胱甘肽过氧化物优于常态组，差异有统计学意义(P<0.05)；考察组不良反应发生率为3.45%，低于常态组的32.14%，差异有统计学意义(P<0.05)。结论 应用570 nm强脉冲光联合果酸治疗黄褐斑可改善患者皮肤状态，减轻氧化应激反应，提高临床疗效，且治疗安全性较高，值得临床应用。

    [关键词] 570 nm强脉冲光；果酸；黄褐斑

    [中图分类号] R758.4+2 [文献标识码] A [文章编号] 1004-4949(2024)13-0066-04

    Clinical Effect of 570 nm Intensive Pulsed Light Combined with Glycolic Acid in the Treatment of Chloasma

    ZHANG Yun-jie

    (Dermatology Department of Chengdu 363 Hospital， Chengdu 610041， Sichuan， China)

    [Abstract]Objective To explore the clinical effect of 570 nm intensive pulsed light combined with glycolic acid in the treatment of chloasma. Methods A total of 57 patients with chloasma admitted to the Department of Dermatology of Chengdu 363 Hospital from May 2022 to February 2023 were randomly divided into normal group (n=28) and observation group (n=29). The normal group was treated with 570 nm intensive pulsed light ......