[摘 要]目的 探讨肉毒素联合脂肪填充在面部年轻化手术中的美容治疗效果。方法 选取沧州美医美医疗美容诊所2021年6月-2022年6月收治的52例拟接受面部塑形的患者为研究对象，随机分为对照组与观察组，每组26例。对照组予以肉毒素治疗，观察组予以肉毒素联合脂肪填充治疗，比较两组临床疗效、面部轮廓参数、皮肤状况及并发症发生情况。结果 观察组治疗总有效率为92.31%，高于对照组的65.38%，差异有统计学意义(P<0.05)；观察组治疗后面下部长度、宽度参数优于对照组，差异有统计学意义(P<0.05)；观察组治疗后暗斑、水润、弹性评分优于对照组，差异有统计学意义(P<0.05)；观察组并发症发生率为19.23%，低于对照组的26.92%，差异有统计学意义(P<0.05)。结论 肉毒素与脂肪填充联合应用可提升面部年轻化效果，改善皮肤轮廓及肤质，减少并发症发生几率，值得临床应用。

    [关键词] 肉毒素；面部年轻化；脂肪填充

    [中图分类号] R622 [文献标识码] A [文章编号] 1004-4949(2024)13-0070-04

    Application of Botulinum Toxin Combined with Fat Filling in Facial Rejuvenation

    GAO Bo1， TONG Xiao-wei2

    (1.Cangzhou Meiyimei Medical Beauty Clinic， Cangzhou 061000， Hebei， China； 2.Shangrao Tong Xiaowei Medical Beauty Dermatology Clinic， Shangrao 334000， Jiangxi， China)

    [Abstract]Objective To investigate the cosmetic effect of botulinum toxin combined with fat filling in facial rejuvenation surgery. Methods From June 2021 to June 2022， 52 patients who were going to receive facial shaping in Cangzhou Meiyimei Medical Beauty Clinic were selected as the research objects and randomly divided into control group and observation group ......