[摘 要]目的 探究在玫瑰痤疮患者治疗中采用精准强脉冲光联合肉毒毒素注射的效果。方法 选取本院2021年9月-2023年8月收治的120例玫瑰痤疮患者为研究对象，采用随机数字表法分为对照组和观察组，各60例。对照组采用精准强脉冲光治疗，观察组采用精准强脉冲光联合肉毒毒素注射治疗，比较两组临床疗效、皮肤屏障功能、皮肤生理指标、美观度、不良反应发生情况。结果 观察组干预后CEA、PGA评分低于对照组(P<0.05)；观察组干预后经皮水分流失量低于对照组，表皮含水量高于对照组(P<0.05)；观察组干预后黑素指数、红斑指数低于对照组(P<0.05)；观察组美观度为96.67%，高于对照组的83.33%(P<0.05)；观察组不良反应发生率为3.33%，低于对照组的8.33%，但差异无统计学意义(P>0.05)。结论 在玫瑰痤疮患者中采用精准强脉冲光联合肉毒毒素注射的效果确切，能改善皮肤屏障功能，提高患者美观度，值得临床应用。

    [关键词] 玫瑰痤疮；精准强脉冲光；肉毒毒素

    [中图分类号] R758.73 [文献标识码] A [文章编号] 1004-4949(2024)14-0001-04

    Effect of Delicate Pulse Light Combined with Botulinum Toxin Injection in the Treatment of Rosacea and its Effect on Aesthetics

    XU Yan-yan， SHENG Liang， QI Jun

    (Department of Dermatology， Guizhou Provincial People’s Hospital， Guiyang 550002， Guizhou， China)

    [Abstract]Objective To explore the effect of delicate pulse light combined with botulinum toxin injection in the treatment of patients with rosacea. Methods A total of 120 patients with rosacea admitted to our hospital from September 2021 to August 2023 were selected as the research objects. They were divided into control group and observation group by random number table method ......