[摘 要]目的 分析强脉冲光联合A型肉毒毒素治疗玫瑰痤疮的临床效果以及对患者皮肤屏障功能和生活质量的影响。方法 选取我院2022年12月-2023年12月收治的50例玫瑰痤疮患者为研究对象，采用随机数字表法分为对照组与观察组，各25例。对照组予以A型肉毒毒素治疗，观察组予以强脉冲光联合A型肉毒毒素治疗，比较两组症候积分、负面情绪、生活质量和不良反应发生情况。结果 观察组红斑、丘疹脓疱、毛细血管扩张、瘙痒积分优于对照组(P<0.05)；观察组治疗后SAS和SDS评分均低于对照组(P<0.05)；观察组不良反应发生率为4.00%，低于对照组的24.00%(P<0.05)；观察组治疗后生活质量评分高于对照组(P<0.05)。结论 使用强脉冲光联合A型肉毒毒素治疗玫瑰痤疮效果较佳，有利于改善患者临床症状与心理状态，减少不良反应的发生几率，优化患者生活质量，值得临床应用。

    [关键词] 强脉冲光；A型肉毒毒素；玫瑰痤疮；皮肤屏障功能

    [中图分类号] R758.73+4 [文献标识码] A [文章编号] 1004-4949(2024)17-0005-04

    Clinical Effect of Intensive Pulsed Light Combined with Type A Botulinum Toxin in the Treatment of Rosacea

    LI Xing-hui， JIANG Yan-nan， LIU Yu， ZHOU Yang

    (Department of Dermatology， Yancheng First People’s Hospital， Yancheng 224000， Jiangsu， China)

    [Abstract]Objective To analyze the clinical effect of intensive pulsed light combined with type A botulinum toxin in the treatment of rosacea and its effect on skin barrier function and quality of life. Methods A total of 50 patients with rosacea admitted to our hospital from December 2022 to December 2023 were selected as the research objects. They were divided into control group and observation group by random number table method ......