[摘 要]目的 探讨氨甲环酸联合氢醌乳膏治疗黄褐斑的临床效果。方法 选取灌云县疾病预防控制中心皮肤病门诊2018年1月-2021年12月收治的60例黄褐斑患者为研究对象，采用随机数字表法分为对照组与观察组，每组30例。对照组采用氢醌乳膏治疗，观察组采用氨甲环酸联合氢醌乳膏治疗，比较两组症状积分、黄褐斑面积及严重程度评分(MASI)、临床疗效、复发率及不良反应发生情况。结果 观察组治疗后症状积分、MASI评分均低于对照组(P<0.05)；观察组显效率高于对照组，有效率、无效率低于对照组(P<0.05)；观察组复发率为6.67%，低于对照组的30.00%(P<0.05)；观察组不良反应发生率为10.00%，略高于对照组的6.67%，但差异无统计学意义(P>0.05)。结论 氨甲环酸联合氢醌乳膏治疗黄褐斑的疗效较好，可改善患者的皮肤状态，缓解临床症状，减少复发几率，且不会增加不良反应发生几率，安全性较高。

    [关键词] 氨甲环酸；氢醌乳膏；黄褐斑

    [中图分类号] R758.4+2 [文献标识码] A [文章编号] 1004-4949(2024)18-0058-03

    Clinical Effect of Tranexamic Acid Combined with Hydroquinone Cream in the Treatment of Chloasma

    KONG Fanlou

    (Skin Disease Outpatient Departmen of Guanyun County Center for Disease Control and Prevention， Lianyungang 222200， Jiangsu， China)

    [Abstract]Objective To investigate the clinical effect of tranexamic acid combined with hydroquinone cream in the treatment of chloasma. Methods A total of 60 patients with chloasma admitted to the Dermatology Clinic of Guanyun County Center for Disease Control and Prevention from January 2018 to December 2021 were selected as the research objects. They were divided into control group and observation group by random number table ......