[摘 要]目的 探讨黄褐斑患者采用果酸换肤联合强脉冲光治疗的效果。方法 选择2020年2月-2024年1月张家港喜悦智美医疗美容诊所收治的66例黄褐斑患者，均为女性，按随机数字表法分为对照组和观察组，各33例。对照组予以强脉冲光治疗，观察组在对照组治疗基础上联合果酸换肤治疗，比较两组临床疗效、皮损改善情况(皮损评分、皮肤角质层含水量与经表皮水分流失量)、氧化应激水平[超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、丙二醛(MDA)]。结果 观察组治疗总有效率为96.97%，高于对照组的78.79%(P<0.05)；观察组治疗后皮损评分、经表皮水分流失量低于对照组，皮肤角质层含水量高于对照组(P<0.05)；观察组治疗后MDA水平低于对照组，SOD、GSP-Px水平高于对照组(P<0.05)。结论 果酸换肤联合强脉冲光可提升黄褐斑患者治疗效果，改善皮损状况、氧化应激水平，值得临床应用。

    [关键词] 果酸换肤；强脉冲光；黄褐斑；皮损情况；氧化应激水平

    [中图分类号] R783.3 [文献标识码] A [文章编号] 1004-4949(2024)18-0065-04

    Effect of Glycolic Acid Peels Combined with Intensive Pulsed Light on Skin Lesions and Oxidative Stress Level in Patients with Chloasma

    ZHOU Wenwen

    (Cosmetic Dermatology Department of Zhangjiagang Xiyue Zhimei Medical Cosmetic Clinic， Zhangjiagang 215699， Jiangsu， China)

    [Abstract]Objective To investigate the effect of glycolic acid peels combined with intensive pulsed light in the treatment of chloasma. Methods From February 2020 to January 2024， 66 female patients with chloasma admitted to Zhangjiagang Joy Chi Mei Medical Cosmetic Clinic were selected and divided into control group and observation group according to random number table method ......