[摘 要]目的 观察应用A型肉毒毒素联合自交联小分子透明质酸改善面部肤质的效果。方法 选取2023年6月-12月我院收治的需改善面部肤质的86例患者为研究对象，随机分为对照组和观察组，每组43例。对照组给予自交联小分子透明质酸治疗，观察组给予A型肉毒毒素联合自交联小分子透明质酸治疗，比较两组临床疗效、面部皮肤指标改善情况及治疗满意度。结果 观察组治疗总有效率为95.35%，高于对照组的76.74%(P<0.05)；观察组治疗后弹性、水分评分均高于对照组，暗斑、油脂评分均低于对照组(P<0.05)；观察组治疗满意度为93.02%，高于对照组的72.09%(P<0.05)。结论 A型肉毒毒素联合自交联小分子透明质酸改善面部肤质的效果良好，可优化面部皮肤指标，提高患者满意度，值得临床应用。

    [关键词] A型肉毒毒素；面部肤质；自交联小分子透明质酸

    [中图分类号] R622 [文献标识码] A [文章编号] 1004-4949(2024)18-0093-04

    Application Effect of Type A Botulinum Toxin Combined with Self-crosslinked Small Molecule Hyaluronic Acid in Improving Facial Skin Texture

    KONG Jie， HU Yang， YU Chunping， WU Jingman

    (Southern Central Hospital of Yunnan Province/the First People’s Hospital of Honghe state， Honghe 661199， Yunnan， China)

    [Abstract]Objective To observe the effect of type A botulinum toxin combined with self-crosslinked small molecule hyaluronic acid on improving facial skin texture. Methods A total of 86 patients who needed to improve facial skin quality in our hospital from June to December 2023 were randomly divided into control group and observation group ......