[摘 要]目的 探讨联用强脉冲光(IPL)与他克莫司软膏治疗红斑毛细血管扩张型玫瑰痤疮(ETR)的有效性及安全性。方法 选取2021年1月-2024年1月南京医科大学友谊整形外科医院收治的52例ETR患者，应用随机数字表法分为干预组、对照组，各26例。对照组予以他克莫司治疗，干预组予以他克莫司+IPL治疗，比较两组临床疗效、症状评分、皮肤障碍功能与不良反应发生情况。结果 干预组治疗总有效率为88.46%，高于对照组的50.00%(P<0.05)；干预组治疗后各症状评分低于对照组(P<0.05)；干预组治疗后皮肤红斑指数指标、经皮水分流失指标、角质层含水量指标优于对照组(P<0.05)；两组不良反应发生率比较，差异无统计学意义(P>0.05)。结论 针对ETR患者，应用IPL+他克莫司软膏能提高总有效率，还能改善患者临床症状及皮肤屏障功能，且安全性高。

    [关键词] 强脉冲光；他克莫司；红斑毛细血管扩张型玫瑰痤疮

    [中图分类号] R758 [文献标识码] A [文章编号] 1004-4949(2024)19-0048-04

    Efficacy and Safety of Intensive Pulsed Light Combined with Tacrolimus Ointment in the Treatment of Erythematotelangiectatic Rosacea

    DU Jiaxi， ZHOU Yujuan， ZHU Yaqian

    (Department of Dermatology， Friendship Plastic Surgery Hospital， Nanjing Medical University， Nanjing 210029， Jiangsu， China)

    [Abstract]Objective To investigate the efficacy and safety of intensive pulsed light (IPL) combined with tacrolimus ointment in the treatment of erythematotelangiectatic rosacea (ETR). Methods A total of 52 patients with ETR admitted to Friendship Plastic Surgery Hospital of Nanjing Medical University from January 2021 to January 2024 were selected and divided into intervention group and control group by random number table method ......