[摘 要]目的 研究超脉冲点阵CO2激光联合富血小板血浆治疗面部痤疮后瘢痕的效果。方法 选择第九〇九医院/厦门大学附属东南医院2023年1月-2024年1月收治的80例面部痤疮后瘢痕患者，按照随机数字表法分为对照组和观察组，每组40例。对照组实施单纯超脉冲点阵CO2激光治疗，观察组实施超脉冲点阵CO2激光联合富血小板血浆治疗，比较两组临床疗效、瘢痕情况、p38MAPK通路蛋白水平、炎性指标及并发症发生率。结果 观察组总有效率为97.50%，高于对照组的80.00%(P<0.05)；观察组治疗后MEK1、MEK2、ERK1、ERK2、INF-γ、IL-6、IL-8水平低于对照组(P<0.05)；观察组并发症发生率低于对照组(P<0.05)。结论 超脉冲点阵CO2激光联合富血小板血浆治疗面部痤疮后瘢痕患者的效果良好，可有效改善瘢痕情况，降低炎性因子水平，安全性较高。

    [关键词] 超脉冲点阵CO2激光；富血小板血浆；面部痤疮；瘢痕

    [中图分类号] R758 [文献标识码] A [文章编号] 1004-4949(2024)20-0052-04

    基金项目：1.漳州市自然科学基金项目(编号：ZZ2023J50)；2.第九〇九医院自主科研项目(编号：22MS006)

    Effect of Ultra-pulsed CO2 Fractional Laser Combined with Platelet-rich Plasma in the Treatment of Scar After Facial Acne

    LIU Shengli1，2， CHEN Daiqing2， DAI Zeyu2

    (1.Graduate School of Fujian Medical University， Fuzhou 350122， Fujian， China； 2.Department of Burn and Plastic Surgery， the 909th Hospital/Dongnan Hospital of Xiamen University， Zhangzhou 363000， Fujian， China)

    [Abstract]Objective To study the effect of ultra-pulsed CO2 fractional laser combined with platelet-rich plasma in the treatment of scars after facial acne. Methods Eighty patients with facial acne scars admitted to the 909th Hospital/Dongnan Hospital of Xiamen University from January 2023 to January 2024 were randomly divided into two groups using a random number table. The control group (n=40) received simple ultra-pulsed CO2 fractional laser treatment ......