[摘 要]目的 探究司库奇尤单抗联合丙酸氟替卡松乳膏治疗寻常型银屑病的效果及对患者皮损程度、炎性反应的影响。方法 选取我院2022年1月-2023年5月收治的40例寻常型银屑病患者为研究对象，随机分为对照组和试验组，各20例，对照组给予卡泊三醇软膏+丙酸氟替卡松乳膏外涂，试验组使用司库奇尤单抗联合丙酸氟替卡松乳膏治疗，比较两组临床疗效、皮损程度及炎症因子水平。结果 试验组治疗总有效率为95.00%，高于对照组的70.00%(P<0.05)；试验组治疗后头颈部、上肢、躯干、下肢皮损面积及红斑、浸润、鳞屑严重程度评分均低于对照组(P<0.05)；试验组治疗后IL-17、IL-10、IL-22水平均低于对照组(P<0.05)。结论 使用司库奇尤单抗联合丙酸氟替卡松乳膏可有效改善寻常型银屑病患者临床症状，同时可改善患者皮损程度，降低机体炎症反应，值得临床使用。

    [关键词] 司库奇尤单抗；寻常型银屑病；皮损程度；炎症反应

    [中图分类号] R758.63 [文献标识码] A [文章编号] 1004-4949(2024)20-0072-04

    Effect of Secukinumab Combined with Fluticasone Propionate Cream on the Degree of Skin Lesions and Inflammatory Response in Patients with Psoriasis Vulgaris

    FEI Shuangxue， GAO Kunping， TANG Mingxiu， YANG Yao， TANG Min

    (Department of Dermatology， Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University， Luzhou 646000， Sichuan， China)

    [Abstract]Objective To explore the therapeutic effect of secukinumab combined with fluticasone propionate cream in patients with psoriasis vulgaris and its influence on the degree of skin lesions and inflammatory response. Methods Forty patients with psoriasis vulgaris admitted to our hospital from January 2022 to May 2023 were randomly divided into control group and experimental group ......