[摘 要]目的 分析在慢性自发性荨麻疹患者中予以氯雷他定片联合维生素D滴剂治疗的效果。方法 选取2023年1月-12月本院收治的72例慢性自发性荨麻疹患者为研究对象，采用随机数字表法分为对照组和观察组，每组36例。对照组给予氯雷他定片治疗，观察组给予氯雷他定片联合维生素D滴剂治疗，比较两组荨麻疹发作情况评分、荨麻疹活动度评分、炎症因子水平及免疫因子水平。结果 观察组治疗后荨麻疹每天发作时间及每天发作次数评分均低于对照组(P<0.05)；观察组治疗后风团及瘙痒评分均低于对照组(P<0.05)；观察组治疗后IFN-γ、TGF-β、IL-4及IL-17水平均低于对照组(P<0.05)；观察组治疗后CD3+、CD4+、CD4+/CD8+均高于对照组，CD8+低于对照组(P<0.05)。结论 氯雷他定片联合维生素D滴剂在慢性自发性荨麻疹患者中的应用效果确切，可有效改善患者的临床症状，减轻炎症，有利于提高免疫水平，促进恢复。

    [关键词] 慢性自发性荨麻疹；氯雷他定片；维生素D滴剂；荨麻疹活动度；炎症因子水平

    [中图分类号] R758.24 [文献标识码] A [文章编号] 1004-4949(2024)22-0037-04

    Application Effect of Loratadine Tablets Combined with Vitamin D Drops in Patients with Chronic Spontaneous Urticaria

    YUAN Hongyan

    (Faculty of Pharmacy， Affiliated Hospital of Beihua University， Jilin 132000， Jilin， China)

    [Abstract]Objective To analyze the effect of loratadine tablets combined with vitamin D drops in patients with chronic spontaneous urticaria. Methods A total of 72 patients with chronic spontaneous urticaria admitted to our hospital from January to December 2023 were selected as the research objects. They were divided into control group and observation group by random number table method ......