[摘 要]目的 探究在面部皮肤老化治疗中应用CO2点阵激光联合重组牛碱性成纤维细胞生长因子的效果。方法 选取扬州市江都妇幼保健院2021年1月-2023年12月收治的86例面部皮肤老化患者为研究对象，根据治疗方法不同分为参照组(n=43)和试验组(n=43)。参照组给予CO2点阵激光治疗，试验组给予CO2点阵激光联合重组牛碱性成纤维细胞生长因子治疗，比较两组临床疗效、皮肤屏障功能、不良反应发生情况及治疗满意度。结果 试验组治疗总有效率为97.67%，高于参照组的86.72%，差异有统计学意义(P<0.05)；试验组治疗后皮肤含水量、经皮水分散失量均优于参照组，差异有统计学意义(P<0.05)；试验组不良反应发生率为0，低于参照组的9.30%，差异有统计学意义(P>0.05)；试验组治疗满意度为100.00%，高于参照组的88.37%，差异有统计学意义(P<0.05)。结论 CO2点阵激光联合重组牛碱性成纤维细胞生长因子治疗面部皮肤老化患者的效果良好，可有效改善患者的皮肤屏障功能，并且能够降低不良反应发生几率，有利于提高治疗满意度，值得临床应用。

    [关键词] CO2点阵激光；重组牛碱性成纤维细胞生长因子；面部皮肤老化；皮肤屏障功能

    [中图分类号] R622 [文献标识码] A [文章编号] 1004-4949(2024)22-0095-04

    Effect of CO2 Fractional Laser Combined with Recombinant Bovine Basic Fibroblast Growth Factor in the Treatment of Facial Skin Aging

    GAO Yuan

    (Dermatology Department of Yangzhou Jiangdu Maternal and Child Health Care Hospital， Yangzhou 225000， Jiangsu， China)

    [Abstract]Objective To explore the effect of CO2 fractional laser combined with recombinant bovine basic fibroblast growth factor in the treatment of facial skin aging. Methods A total of 86 patients with facial skin aging admitted to Yangzhou Jiangdu Maternal and Child Health Hospital from January 2021 to December 2023 were selected as the research objects. According to different treatment methods ......