[摘 要]目的 探讨中重度痤疮患者采用果酸联合多西环素治疗的临床效果。方法 选取2022年7月-2024年6月金乡县人民医院收治的60例中重度痤疮患者为研究对象，按照随机数字表法分成对照组(n=30)和观察组(n=30)。两组均接受夫西地酸乳膏治疗，对照组给予多西环素治疗，观察组给予果酸联合多西环素治疗，比较两组临床疗效、皮损严重程度、色素沉着改善情况及不良反应发生情况。结果 观察组治疗总有效率为93.33%，高于对照组的70.00%，差异有统计学意义(P<0.05)；两组治疗后GAGS评分均低于治疗前，且观察组低于对照组，差异有统计学意义(P<0.05)；观察组治疗后PAHPI评分低于对照组，差异有统计学意义(P<0.05)；观察组不良反应发生率为10.00%，低于对照组的16.67%，但差异无统计学意义(P>0.05)。结论 中重度痤疮患者采用果酸联合多西环素治疗可促进临床疗效提升，减轻皮损严重程度和色素沉着，且不会增加不良反应发生风险，值得临床应用。

    [关键词] 果酸；多西环素；中重度痤疮；皮损严重程度

    [中图分类号] R758.73+3 [文献标识码] A [文章编号] 1004-4949(2024)23-0013-04

    Clinical Effect of Glycolic Acid Combined with Doxycycline in the Treatment of Moderate to Severe Acne

    SUN Qijun

    (Department of Dermatology， Jinxiang County People’ s Hospital， Jining 272200， Shandong， China)

    [Abstract]Objective To investigate the clinical effect of glycolic acid combined with doxycycline in the treatment of patients with moderate to severe acne. Methods Sixty patients with moderate to severe acne admitted to Jinxiang County People’s Hospital from July 2022 to June 2024 were selected as the research objects. They were divided into group control (n=30) and observation group (n=30) by random number table method. Both groups were treated with fusidic acid cream. The control group was treated with doxycycline ......