[摘 要]目的 探究在面部除皱中应用A型肉毒毒素联合透明质酸钠凝胶的效果。方法 选择2022年1月-12月于我院行面部除皱的60例患者为研究对象，采用随机数字表法分为对照组及观察组，各30例。对照组采用A型肉毒毒素治疗，观察组采用A型肉毒毒素联合透明质酸钠凝胶治疗，比较两组临床疗效、生活质量、满意度及不良反应发生情况。结果 观察组治疗总有效率为100.00%，高于对照组的73.33%(P<0.05)；观察组治疗后物质生活、躯体功能、心理功能、社会功能评分均高于对照组(P<0.05)；观察组满意度为100.00%，高于对照组的73.33%(P<0.05)；观察组不良反应发生率为6.67%，低于对照组10.00%，但差异无统计学意义(P>0.05)。结论 A型肉毒毒素联合透明质酸钠凝胶在面部除皱中的应用效果确切，可有效减轻面部皱纹，有利于提高患者生活质量及满意度，且治疗后不良反应发生率较低，应用安全性较高。

    [关键词] A型肉毒毒素；透明质酸钠凝胶；面部除皱

    [中图分类号] R622 [文献标识码] A [文章编号] 1004-4949(2024)23-0086-04

    Application Effect of Type A Botulinum Toxin Combined with Sodium Hyaluronate Gel in Facial Wrinkle Removal

    LI Xia

    (Sichuan Huamei Zixin Medical Cosmetology Hospital， Chengdu 610000， Sichuan， China)

    [Abstract]Objective To explore the effect of type A botulinum toxin combined with sodium hyaluronate gel in facial wrinkle removal. Methods A total of 60 patients who underwent facial rhytidectomy in our hospital from January to December 2022 were selected as the research objects. They were divided into control group and observation group by random number table method， with 30 patients in each group. The control group was treated with type A botulinum toxin ......