[摘 要]目的 分析对难治性白癜风给予308 nm准分子光联合二氧化碳点阵激光治疗的有效性及安全性。方法 选择我院2022年12月-2024年4月收治的60例难治性白癜风患者为研究对象，以随机数字表法分为对照组(n=30)和研究组(n=30)。对照组采用308 nm准分子光治疗，研究组采用308 nm准分子光联合二氧化碳点阵激光治疗，比较两组临床疗效、不良反应发生情况、炎性因子水平及白斑面积。结果 研究组治疗总有效率96.67%，高于对照组的76.67%(P<0.05)；两组不良反应发生率比较，差异无统计学意义(P>0.05)；两组治疗后IgG、IL-17水平均低于治疗前，且研究组低于对照组(P<0.05)；两组治疗后白斑面积均小于治疗前，且研究组小于对照组(P<0.05)。结论 308 nm准分子光联合二氧化碳点阵激光治疗难治性白癜风的效果良好，可有效抑制炎性因子水平，缩小白斑面积，且不会增加不良反应发生风险，应用有效性及安全性均较高。

    [关键词] 308 nm准分子光；二氧化碳点阵激光；难治性白癜风；炎性因子水平；白斑面积

    [中图分类号] R758.4+1 [文献标识码] A [文章编号] 1004-4949(2024)23-0106-04

    Efficacy and Safety of 308 nm Excimer Laser Combined with Carbon Dioxide Fractional Laser in the Treatment of Refractory Vitiligo

    HU Hao

    (Dermatology Department of Baoying County People’s Hospital， Yangzhou 225800， Jiangsu， China)

    [Abstract]Objective To analyze the efficacy and safety of 308 nm excimer light combined with carbon dioxide fractional laser in the treatment of refractory vitiligo. Methods A total of 60 patients with refractory vitiligo admitted to our hospital from December 2022 to April 2024 were selected as the research objects. They were divided into control group (n=30) and study group (n=30) by random number table method. The control group was treated with 308 nm excimer light ......