[摘 要]目的 探究多西环素联合红蓝光照射在玫瑰痤疮治疗中的临床效果。方法 选取本院2022年3月-2024年3月收治的60例玫瑰痤疮患者作为研究对象，采用随机数字表法分为对照组和观察组，各30例。两组均接受常规治疗干预，其中对照组在常规治疗基础上给予红蓝光照射治疗，观察组联合多西环素、红蓝光照射治疗，比较两组临床疗效、炎症因子水平、皮肤生理功能、皮损评分及生活质量。结果 观察组临床总有效率为96.67%，高于对照组的80.00%(P<0.05)；观察组治疗后IL-6、CRP、TNF-α、经皮水分流失量、表皮含水量、油脂、各项皮损评分以及各维度生活质量评分优于对照组(P<0.05)。结论 多西环素联合红蓝光治疗能够切实提高玫瑰痤疮患者的临床疗效，抑制炎症因子水平，改善患者皮肤状况及皮损情况，从而提高其生活质量。

    [关键词] 多西环素；红蓝光照射；玫瑰痤疮；皮肤生理功能

    [中图分类号] R758.73+3 [文献标识码] A [文章编号] 1004-4949(2024)24-0069-04

    Effect of Doxycycline Combined with Red and Blue Light Irradiation in the Treatment of Acne Rosacea and its Influence on the Inflammatory Factor Levels and Skin Physiological Function

    YANG Yujia

    (Department of Dermatology， Ehu Branch of Xishan People’s Hospital ， Wuxi 214100， Jiangsu， China)

    [Abstract]Objective To investigate the clinical effect of doxycycline combined with red and blue light irradiation in the treatment of acne rosacea. Methods A total of 60 patients with acne rosacea admitted to our hospital from March 2022 to March 2024 were selected as the research subjects， and they were divided into control group and observation group by the random number table method ......