Analysis of the effect of dietary factors on irritable bowel syndrome by Mendelianrandomizedmethod

    1.2.3， Yanping1，2.3， WANG Huimin1.2.3， MA Xiaotong12.3， GUO Qinghong2，3，

    CHEN Zhaofeng2.3

    1. TheFirstClinicalMedicalSchool，Lanzhou University，Lanzhou73oooo，China

    2.DepartmentofastroenterologyTheFirstHospitalofanzhouUniversity，Lanzhou73ooo，China

    3.Gansu Clinical Medical Research CenterforDigestiveDiseases，Lanzhou 73oooo，China

    Correspondingauthor：CHENZhaofeng，Email： zhfchen@lzu.edu.cn

    【Abstract】 Objective To explore the causal relationship between dietary factors and the risk of developing irritable bowel syndrome (IBS) through Mendelian randomization analysis. Methods In the study， dietary factor-related characteristics from published Genome-Wide Association Study (GWAS) were selected and extracted as instrumental variables， and GWAS data on IBS were obtained from FinnGen Database.A two-sample Mendelian randomization analysis was primarily performed using the inverse variance weighted (IVW) method， and the test of heterogeneity，the testof pleiotropy ......